Methotrexate-related lymphoproliferative disorder in patients with osteonecrosis of the jaw
نویسندگان
چکیده
منابع مشابه
Oral Methotrexate-related Lymphoproliferative Disease Presenting with Severe Osteonecrosis of the Jaw: A Case Report and Literature Review
Long-term methotrexate (MTX) treatment can cause MTX-related lymphoproliferative disorder (MTX-LPD). We experienced a case of MTX-LPD that was associated with severe osteonecrosis of the jaw mimicking medication-related osteonecrosis of the jaw. The patient was an 81-year-old woman with rheumatoid arthritis (RA) who was treated with MTX and bisphosphonate. After 7 years, she was referred to our...
متن کاملMedication-Related Osteonecrosis of the Jaw
Osteonecrosis of the jaw (ONJ) is a common side effect of antiresorptive drugs that are administered to cancer patients for bone metastasis, multiple myeloma, and osteoporosis. Since both bisphosphonate (BP) and denosumab show anti-bone resorption effects with ONJ, antiresorptive agent-related ONJ (ARONJ) has been suggested as a comprehensive term encompassing both BP-related osteonecrosis of t...
متن کاملBisphosphonate-related osteonecrosis of the jaw
Bisphosphonates (BPs) have been used for the management of bone metabolic diseases. Currently their therapeutic use has increased, as also have their adverse effects, one of the most important being the bisphosphonate-related osteonecrosis of the jaw (BRONJ), a complication of diffi cult treatment and solution. Until now, the physiopathology of BRONJ remains unclear, and its treatment is uncert...
متن کاملBisphosphonate-Related Osteonecrosis of the Jaw: Specificities
Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a severe complication that has recently emerged in patients treated with intravenous bisphosphonates for malignant diseases. This complication usually presents after a minor local trauma during a dental treatment. Several etiopathogenic mechanisms of this pathological condition have been proposed, but no model can explain all morpholog...
متن کاملBisphophonates related osteonecrosis of the jaw
OBJECTIVE With sporadic reporting of BPs related osteonecrosis of jaw and in absence of definitive guidelines regarding the management of such patients, the dentists and the oral and maxillofacial surgeons need to be updated about this issue. The objective of this article was to produce an updated bibliographic review of BPs related ONJ. This paper reviews the literature regarding the same for ...
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ژورنال
عنوان ژورنال: International Journal of Oral and Maxillofacial Surgery
سال: 2017
ISSN: 0901-5027
DOI: 10.1016/j.ijom.2017.02.493